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Global aviation news tracker
Global aviation news tracker

MightyFly will deploy MF-100 cargo drones to start medical drone deliveries across California under a $50 million contract, with initial operations slated for Q4 2025.
MightyFly, a US-based hybrid-electric cargo drone manufacturer, has won a $50 million contract to run medical drone deliveries in California in partnership with a major healthcare logistics provider. The company says the operation will use its MF-100 model, a heavy-lift unmanned cargo aircraft designed for long-range point-to-point logistics.
The MF-100 can carry up to 100 pounds of cargo and has an advertised range of about 600 miles, giving operators flexibility for rural-to-urban routes and interfacility transfers. MightyFly plans initial flights in Q4 2025, positioning the rollout as one of the larger US medical drone logistics deployments to date.
Regulatory and logistics hurdles remain: airspace integration with manned traffic, state and local approvals, and coordination with existing ground networks. The deal signals growing industry confidence in unmanned aerial vehicles (UAVs) for critical supply chains, particularly for time-sensitive medical payloads like blood, vaccines, and emergency equipment.
Industry observers say large contracts like this accelerate infrastructure investment: from vertiports and charging/refueling hubs to software for route management, remote pilot oversight, and maintenance. For communities with limited road access or congested urban corridors, aerial delivery can cut transit times and reduce spoilage for temperature-sensitive goods.
Expect regulators and local authorities in California to outline phased approvals and public notifications ahead of the first flights. MightyFly’s deployment will be a useful case study for how hybrid-electric cargo drones move from trial phases into commercial, day-to-day medical logistics.